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KMID : 0828520140180020085
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Journal of the Korean Geriatrics Society
2014 Volume.18 No. 2 p.85 ~ p.88
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Valacyclovir-Induced Neurotoxicity in a Maintenance Hemodialysis Patient
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Hwang June-Seong
Song Hyo-Yeop
Jo Hoon-Gil
Lee Song-I
Lim Byung-Hun
Song Jung-Sub
Ahn Seon-Ho
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Abstract
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Valacyclovir is an oral antiviral agent used in the treatment of herpesvirus infection. Although neuropsychiatric symptoms may accompany the use of this drug, valacyclovir is increasingly used to treat herpes zoster, as it is more effective when orally administered. This paper reports one case of neurotoxicity of valacyclovir in patients with end stage renal disease who were undergoing maintenance hemodialysis. Valacyclovir can induce life-threatening neurotoxicity, especially in end stage renal disease patients despite the appropriate dose reduction. Furthermore, Valacyclovir-induced neurotoxicity can be effectively managed by intensive hemodialysis.
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KEYWORD
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End-stage renal disease, Hemodialysis, Neurotoxicity, Valacyclovir
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